Hemostasis, Platelet Aggregation Reagents

Platelet Aggregation Reagents

Platelet Aggregation Kit

Cat. No.	Item
5369	Platelet Aggregation Kit ADP Reagent, 2 x 1 mL Collagen Reagent, 2 x 1 mL Epinephrine Reagent, 2 x 1 mL

The Platelet Aggregation Kit is used to identify normal and abnormal platelet function, to quantitate platelet response and to determine the patient's response to anti-platelet drug therapy. The reagents are optimized for use with the Helena AggRAM analyzer, but may be used on any turbidometric aggregometer of similar quality.

ADP Reagent

Cat. No.	Item
5366	ADP, 2 x 1 mL

ADP is a lyophilized preparation of adenosine-5-diphosphate. ADP is for use in routine platelet aggregation studies for the evaluation of qualitative platelet function disorders. The concentration of the reconstituted ADP reagent is 200 mM.

Collagen Reagent

Cat. No.	Item
5368	Collagen, 2 x 1 mL

The collagen reagent is a clear, stabilized liquid reagent which is one of the world's best collagen preparations. Collagen is for use in routine platelet aggregation studies for the evaluation of qualitative platelet function disorders. The concentration of the collagen reagent (equine tendon) is 100 mg/mL.

Epinephrine Reagent

Cat. No.	Item
5367	Epinephrine, 2 x 1 mL

Epinephrine is a lyophilized preparation of L-epinephrine bitartrate. Epinephrine is for use in routine platelet aggregation studies for evaluation of qualitative platelet function disorders. After reconstitution, epinephrine concentration is 3 mM.

Arachidonic Acid

Cat. No.	Item
5364	Arachidonic Acid, 2 x 1 mL

Arachidonic Acid is a lyophilized preparation of sodium arachidonate for use in platelet aggregation studies of abnormal function, especially dysfunction induced by aspirin and aspirin-containing medications.

Ristocetin (for Aggregation Assays)

Cat. No.	Item
5199	Ristocetin, 10 x 0.5 mL

This Ristocetin is for use in platelet aggregation studies for confirmation of von Willebrand Disease (vWD) and Bernard-Soulier Syndrome. Normal platelet-rich plasma exhibits a positive aggregation response to the addition of ristocetin using a final concentration of 12-15 mg/mL. The majority of vWD patients exhibit a negative response to ristocetin as do Bernard-Soulier patients.

Helena Ristocetin Cofactor Assay Kit

Cat. No.	Item
5370	Ristocetin Cofactor Kit, 50 tests Lyophilized Platelets, 4 x 5.0 mL Ristocetin Cofactor Abnormal Control, 2 x 0.5 mL S.A.R.P. Assayed Reference Plasma, 2 x 1.0 mL Helena Ristocetin - 10 mg/mL, 2 x 1.5 mL Tris-Buffered Saline, 1 x 35 mL

Ristocetin cofactor assays measure the ability of von Willebrand factor (Ristocetin cofactor) in the patient's plasma to agglutinate formalinized platelets in the presence of ristocetin. Decreased levels of ristocetin cofactor activity are associated with von Willebrand Disease.

Lyophilized Platelets

Cat. No.	Item
5356	Lyophilized Platelets, 5 x 10 mL
5371	Lyophilized Platelets, 5 x 5 mL

Lyophilized Platelets are a standardized suspension of fixed platelets derived from platelet concentrate. Lyophilized Platelets are for use in the quantitation of ristocetin cofactor activity in plasma. The platelets are lyophilized for stability. Tris-Buffered Saline (Cat. No. 5365) should be used for reconstitution. The concentration of the reconstituted platelet suspension is approximately 200,000/mL. Platelets in Cat. No. 5356 show a slower reaction rate.

Ristocetin Cofactor Abnormal Control Plasma

Cat. No.	Item
5373	Ristocetin Cofactor Abnormal Control, 5 x 0.5 mL

The control is to be used in the assay of ristocetin cofactor. It contains citrated human plasma with a level of ristocetin cofactor activity below 50%.

Ristocetin - 10 mg/mL
(for Ristocetin Cofactor Assays)

Cat. No.	Item
5372	Ristocetin - 10 mg/mL, 5 x 1.5 mL

The reagent is to be used in the quantitative determination of ristocetin cofactor activity. The ristocetin reagent is prepared from Nocardia lurida and is used in the tests for von Willebrand Disease and Bernard-Soulier Syndrome.

Tris-Buffered Saline

Cat. No.	Item
5365	Tris-Buffered Saline, 1 x 125 mL

Tris-Buffered Saline is used for reconstitution and dilution of some of the reagents used in platelet aggregation assays and ristocetin cofactor assays.